Centrul Lyme

Jarisch-Herxheimer Reaction in Lyme Disease

In 7-30% of Lyme disease cases, antibiotic treatment triggers the Jarisch-Herxheimer reaction. This entails a worsening of symptoms over a period ranging from several days to a few weeks 1.

This response occurs due to the rapid destruction of a large number of microorganisms, leading to the release of non-endotoxin pyrogens and lipoproteins into the bloodstream 2. These toxins stimulate a robust pro-inflammatory response.

Research indicates that the severity of the reaction correlates with the bacterial load of the infected individual 3. Also referred to as the "healing crisis," the Jarisch-Herxheimer reaction serves as compelling evidence of the effectiveness of the antibiotic regimen or therapy being administered.

Detoxification therapies

Given this phenomenon, our clinic places significant emphasis on detoxification therapies aimed at improving liver and kidney function.


1. Butler, Thomas. "The Jarisch–Herxheimer reaction after antibiotic treatment of spirochetal infections: a review of recent cases and our understanding of pathogenesis." The American journal of tropical medicine and hygiene 96.1 (2017): 46.
2. Nykytyuk, Svitlana, et al. "The Jarisch-Herxheimer reaction associated with doxycycline in a patient with Lyme arthritis." Reumatologia 58.5 (2020): 335.
3. Breuer, Adin, et al. "Quantitative real-time PCR in Borrelia persica tick-borne relapsing fever demonstrates correlation with the Jarisch-Herxheimer reaction." European Journal of Clinical Microbiology & Infectious Diseases 40.5 (2021): 1113-1116.

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Phone: +40.771.518.946, e-mail: office@imuno-medica.ro