Photodynamic Therapy (PDT)

Photodynamic therapy, which is used in the ImunoMedica clinic, is an effective cancer treatment method. Contrary to chemotherapy, this therapy does not affect the immune function; instead, an immunising effect is seen as a result of the use of this technique. As a result, photodynamic therapy can also be used in immunocompromised patients.
At the Immunomedica clinic, a photosensitizing drug is administered intravenously or directly into the tumor. The photosensitizer binds to pathologically altered tissue with extremely high specificity. After a predetermined time interval, light is delivered intravenously or externally via a laser of the appropriate wavelength. This is absorbed by the targeted cells, resulting in the production of reactive oxygen species that destroy tumor cells via apoptosis, necrosis, or alteration of the tumor vasculature.  

Photosensitizers currently used orally or by infusion

•    riboflavin
•    hypericin
•    Chlorine E6
•    indocyanine green
•    curcumin


•    tumoral diseases
•    viral diseases (hepatitis, HIV, herpes, etc.)
•    bacterial infections
•    chronic Lyme disease
•    multidrug-resistant staphylococci

•    parasitic diseases


Applications of photodynamic therapy in the immunoMedica clinic



A description of photodynamic cancer therapy used in combination with liposomal indocyanine green as a photosensitizer and infrared laser light, ultrasounds, and shock waves as stimulators.
Weberneedle® Endo laser interstitial photodynamic therapy in breast cancer
Practical application of photodynamic therapy with infrared laser light (100 mW, 810 nm) after administration of liposomal indocyanine green as a photosensitizer in breast cancer.
External photodynamic therapy for squamous cell carcinoma of the tongue and lymph node metastases
Laser Clinical application of external infrared laser therapy (100 mW, 810 nm) after delivery of liposomal indocyanine green as a photosensitizer via laser shower.




Infrared 810 nm

Indocyanine green (ICG) absorbs light in the infrared spectrum

Red 635 and 658 nm

Chlorin E6 is combined with the red laser

Blue 405 and 447 nm

447 nm blue laser can be used as a photosensitizer in combination with riboflavin or curcumin

Yellow 589 nm

Hypericin, derived from St. John's wort, is the most potent natural photosensitizer, absorbing yellow light (590 nm).

UV 375 nm

Ultraviolet light deactivates pathogens and stimulates the immune system.


dos Santos, Ancély Ferreira, et al. "Photodynamic therapy in cancer treatment-an update review." Journal of cancer metastasis and treatment 5 (2019): 25.
Hamblin, Michael R. "Photodynamic therapy for cancer: what's past is prologue." Photochemistry and photobiology 96.3 (2020): 506-516.
Mansoori, Behzad, et al. "Photodynamic therapy for cancer: Role of natural products." Photodiagnosis and photodynamic therapy 26 (2019): 395-404.
Muniyandi, Kasipandi, et al. "Role of photoactive phytocompounds in photodynamic therapy of cancer." Molecules 25.18 (2020): 4102.
Zhou, Zijian, et al. "Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy." Chemical Society Reviews 45.23 (2016): 6597-6626.
Debele, Tilahun Ayane, Sydney Peng, and Hsieh-Chih Tsai. "Drug carrier for photodynamic cancer therapy." International journal of molecular sciences 16.9 (2015): 22094-22136.
Sobhani, Nafiseh, and Ali Akbar Samadani. "Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically." Journal of the Egyptian National Cancer Institute 33.1 (2021): 1-13.