Photodynamic Therapy (PDT)

Photodynamic Therapy (PDT)

Photodynamic therapy, applied at ImunoMedica clinic, represents an efficient approach for treating cancer. In contrast to standard chemotherapy, this method doesn't impact the immune function; instead, an immunization phenomenon is observed following the utilization of this technique. Thus, photodynamic therapy proves to be a viable option even for immunosuppressed patients.

At the ImunoMedica clinic, the patient receives a photosensitizing agent either intravenously or directly into the tumor. This photosensitizer binds specifically to the altered pathological tissue. Following a specific interval, light is applied using a laser at an appropriate wavelength, either intravenously or externally.

This light is absorbed by the targeted cells, triggering the production of reactive oxygen species that ultimately lead to the destruction of tumor cells through processes such as apoptosis, necrosis, or alteration of tumor vascularization.

currently used orally
or by infusion

  • riboflavin
  • hypericin
  • Chlorine E6
  • indocyanine green
  • curcumin


Applications of photodynamic therapy
in the ImunoMedica clinic


A description of photodynamic cancer therapy used in combination with liposomal indocyanine green as a photosensitizer and infrared laser light, ultrasounds, and shock waves as stimulators.


Weberneedle® Endo laser interstitial photodynamic therapy in breast cancer

Practical application of photodynamic therapy with infrared laser light (100 mW, 810 nm) after administration of liposomal indocyanine green as a photosensitizer in breast cancer.


External photodynamic therapy for squamous cell carcinoma of the tongue and lymph node metastases

Clinical application of external infrared laser therapy (100 mW, 810 nm) after delivery of liposomal indocyanine green as a photosensitizer via laser shower.


  • Infrared 810 nm

    Indocyanine green (ICG) absorbs light in the infrared spectrum.

  • Red 635 and 658 nm

    Chlorin E6 is combined with the red laser.

  • Blue 405 and 447 nm

    447 nm blue laser can be used as a photosensitizer in combination with riboflavin or curcumin.

  • Yellow 589 nm

    Hypericin, derived from St. John's wort, is the most potent natural photosensitizer, absorbing yellow light (590 nm).

  • UV 375 nm

    Ultraviolet light deactivates pathogens and stimulates the immune system.

For more information go to the Photodynamic Therapy (PDT) page


dos Santos, Ancély Ferreira, et al. "Photodynamic therapy in cancer treatment-an update review." Journal of cancer metastasis and treatment 5 (2019): 25.
Hamblin, Michael R. "Photodynamic therapy for cancer: what's past is prologue." Photochemistry and photobiology 96.3 (2020): 506-516.
Mansoori, Behzad, et al. "Photodynamic therapy for cancer: Role of natural products." Photodiagnosis and photodynamic therapy 26 (2019): 395-404.
Muniyandi, Kasipandi, et al. "Role of photoactive phytocompounds in photodynamic therapy of cancer." Molecules 25.18 (2020): 4102.
Zhou, Zijian, et al. "Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy." Chemical Society Reviews 45.23 (2016): 6597-6626.
Debele, Tilahun Ayane, Sydney Peng, and Hsieh-Chih Tsai. "Drug carrier for photodynamic cancer therapy." International journal of molecular sciences 16.9 (2015): 22094-22136.
Sobhani, Nafiseh, and Ali Akbar Samadani. "Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically." Journal of the Egyptian National Cancer Institute 33.1 (2021): 1-13.

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