Hyperbaric oxygen therapy and fertility in women

Hyperbaric oxygen therapy helps substantially in preventing and treating infertility in women. Hyperbaric chamber increases fertility by improving ovulation and egg quality and reducing endometriosis
In recent years, hyperbaric chamber earned its well-deserved place among the therapies that treat holistically(1) infertility because it improves the health of the whole organism by increasing angiogenesis, reducing inflammation and tissue lesions, and relief of chronic exhaustion. All these effects stimulate fertility in men and women, mainly because the reproductive system functions well when the organism is full of energy and does not present excess inflammation.

Fertility in women decreases naturally with age due to the decrease in oocyte quality and ovarian reserve. Usually, the probability of a healthy woman over 30 years old getting pregnant is 20%, while after 40 years old, the fertility decreases to 5%. Besides sub-optimal ovulation, other risk factors are the thickness of the endometrium (internal mucous of the uterus), essential for supporting the egg and embryo, the development of uterine fibroids, and endometriosis.

Clinical experience shows that hyperbaric oxygen improves fertility in women by contributing to the well-functioning uterus and ovaries. Here is why:

Improves ovulation
A study(2) conducted in 2014 by a team of doctors in Mexico on several patients diagnosed with infertility recorded a significant increase in serum level of the Anti-Müllerian Hormone by 116% after the hyperbaric oxygen therapy. Furthermore, the clinical experience shows that hyperbaric oxygen is an alternative treatment for women with a reduced ovarian reserve. Thus, hyperbaric chamber contributes substantially to improving ovulation and the quality of the ovule.

Increases follicular angiogenesis
Angiogenesis is essential for follicular development, having an important role in the oocytes' quality and the embryo's early development. A pilot study(3) conducted by the University of Iowa (USA) on a group of patients diagnosed with infertility showed an increased level of VEGF (Vascular endothelial growth factor) in the follicular fluid in the women treated with hyperbaric oxygen, compared with the control group. It is well-known that VEGF plays a vital role in increasing follicular angiogenesis.

Increases the thickness of endometrium
One cause of infertility in women can be generated by problems in endometrial receptivity, meaning a lower quality of the uterine mucous in which the embryo develops. Hyperbaric oxygen prepares the endometrium and improves its quality through increased blood flux and oxygen intake(4).

Reduces endometriosis and pelvic inflammatory disorder 
Inflammation caused by both disorders can negatively affect fertility. Hyperbaric oxygen is beneficial by reducing inflammation. In patients diagnosed with endometriosis, hyperbaric oxygen therapy's anti-inflammatory effect reduces the anti-inflammatory response of TLR4 on different organs, reducing chronic inflammation at a systemic level. Hyperbaric oxygen improves oxygen flow and vascularization in endometriosis, improving the quality of oocytes, the response to ovarian stimulation, and the embryo quality.

Reduces uterine scarring 
Uterine scarring can decrease women's fertility. Studies have shown that hyperbaric oxygen can be used both in preventing uterine scarring and in healing damaged tissue.

Based on international research and its own therapeutic experience, ImunoMedica Clinic recommends the hyperbaric chamber as part of the strategy to stimulate fertility in women through non-invasive and safe methods. Procedures often risky in the long term, like in-vitro fertilization and insemination, are highly costly, while a complete hyperbaric cycle is about 10 times more convenient.

(1)Feng, Jiaxing, et al. "The Efficacy of Complementary and Alternative Medicine in the Treatment of Female Infertility.” Evidence-Based Complementary and Alternative Medicine: ECAM, vol. 2021, 2021,, 10.1155/2021/6634309
(2)Pineda, J. F. G. (2015, May 1). Improvement in Serum Anti-Müllerian Hormone Levels in Infertile Patients after Hyperbaric Oxygen (preliminary results). Retrieved October 19, 2022, from
(3)VANVOORHIS, B, et al. "Hyperbaric Oxygen and Ovarian Follicular Stimulation for in Vitro Fertilization: A Pilot Study.” Fertility and Sterility, vol. 83, no. 1, Jan. 2005, pp. 226–228, 10.1016/j.fertnstert.2004.05.101. Accessed 16 June 2022.
(4)Mitrović, Ana, et al. "HYPERBARIC OXYGENATION as a POSSIBLE THERAPY of CHOICE for INFERTILITY TREATMENT.” Bosnian Journal of Basic Medical Sciences, vol. 6, no. 2, 1 May 2006, pp. 21–24,

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